Contact information:

University of Miami,

Department of Human Genetics,

1501 NW 10th Ave,

Office: BRB 709A

Lab: BRB 742F,

Locator code: C227,

Miami, FL 33136

Office phone: (305) 243-7333

Lab Phone: (305) 243-2237

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The Figueroa lab studies the role of epigenetic modifications in transcriptional regulation during normal and malignant hemopoiesis. Our focus is mainly on how changes in normal DNA methylation and hydroxymethylation patterns occur during malignant transformation and how these changes may contribute to the leukemogenic process. We use a combination of computational approaches based on genome-wide next generation sequencing data as well as in vitro and in vivo modeling to determine the consequences of the epigenetic lesions that we have identified. 

Epigenetic Regulation of Hematopoiesis